Antidepressant reviews from Reddit

Summary

We analyzed 529 Reddit reviews across 38 subreddits and 90 posts to rank the best Antidepressant brands recommended by redditors, including communities like r/antidepressants, r/Anxiety, r/PCOS, r/depression, r/depression_help. Top-rated brands include Sertraline (3.7/5), Bupropion (4.0/5), Escitalopram (3.9/5).

Stats

Reviews529

Subreddits38

Posts90

Brands81

Products14

Top communities

r/antidepressants209 r/Anxiety93 r/PCOS26 r/depression25 r/depression_help16

529 reviews from

and

By Brand

By Product

Sertraline

3.7

(45)

"A combo of Zoloft and Seroquel for OCD with Ativan for panic attacks has given me my life back"

"Is a miracle elixir that grants me the power of not catastrophizing EVERYTHING"

"Sertraline changed my life."

"Sertraline (Zoloft) has been a life saver for me."

"I'm on sertraline and love it, it's helped me so so much."

"I’m on Zoloft but that’s for PPD. It has helped me a lot."

"I'm on Zoloft and it helps me tremendously."

"I’ve been on sertraline! I was on Mirtazpine for between 2 to 3 years."

"I take Sertraline (generic Zoloft) for 7-10 days before my period and it’s amazing."

"My best combo is zoloft and trittico +supliments"

Bupropion

4.0

(40)

"+1 for bupoprion, I recently got on it and recommend it highly! It was like flipping a switch for me."

"Wellbutrin works the best for me. Lexapro made me want to go to sleep forever and I got off that QUICK."

"Wellbutrin is amazing and sometimes also prescribed to help with weight management."

"I LOVED Wellbutrin. Gave me energy, I lost weight, felt great."

"I’ve had success with Bupropion!"

"Wellbutrin (bupropion) FOR SURE, it’s the one med that actually gave me energy and laughter."

"It has made the world of difference."

"If you want to avoid SSRIs, Wellbutrin has been a wonder drug for me."

"Glad I read your whole thread because I was going to suggest Wellbutrin! 😅 I stopped taking it recently and my Strattera is not working as well."

"I also take bupropion which tends to make me anxious but does give me energy which helps w my depression"

Escitalopram

3.9

(39)

"Lexapro is the best so far"

"Lexapro has been the best out of 5 for me."

"It is the best."

"I started on escitalopram (lexapro) a few months ago and it’s changed my life."

"I take lexapro and it works like a dream."

"Lexapro 3 years"

"Lexapro was the one that actually calmed my racing thoughts down and the depression that goes with this illness."

"Lexapro, it really is trial and error. It takes months for it to work effectively so even if the medication doesn’t seem like it works initially you have to give it time."

"I had great success with Lexapro, but for some people it’s intolerable."

"Lexapro for me."

Wellbutrin

4.2

(36)

"It’s been a lifesaver for both anxiety and depression."

"I’m totally stable & mellow, best feeling ever."

"If it’s mainly depression (Wellbutrin, like you mentioned."

"Welbutrin is great actually made me lose weight"

"There are non-SSRI options like Wellbutrin that are effective for many people."

"Wellbutrin has changed my life"

"I have had really great luck with Wellbutrin when I was younger and prozac now!"

"I’ve not experienced any side effects, and it’s helped me feel better."

"Echoing those who have had success with Wellbutrin/Bupropion."

"Wellbutrin and labetelol"

Fluoxetine

4.3

(31)

"I’ve been on just about everything in every class and Prozac was the best."

"I did best on Prozac."

"Fluoxetine helps me immensely."

"Has helped me so much, with very little to no side effect"

"Did wonders for me!! 20mg!!"

"Prozac works really well for me as as anti depressant and massively reduced my anxiety!"

"But Prozac worked best for me in terms of doing what you asked."

"Fluoxetine/Prozac - it has been the best by far!! No sexual side effects, happier, less anxiety."

"It has little to no side effects for them."

"I take prozac and it helps me so much."

Duloxetine

4.2

(24)

"I did best on Cymbalta!! I’ve been on it over a year and I love it for my anxiety."

"It’s been a lifesaver for both anxiety and depression."

"Duloxetine (Cymbalta) made a dramatic difference for me."

"Cymbalta has been wonderful. It’s almost nonexistent now."

"Cymbalta has been wonderful for me."

"It’s my duloxetine+abilify+hydroxyzine combo. i’m alive and chilling because of them."

"Cymbalta does wonders for my anxiety."

"Cymbalta 90mg has made my GAD almost non existent."

"Duloxetine/Cymbalta"

"Now duloxetine(Cymbalta) for 3.5 years"

Zoloft

4.0

(23)

"Zoloft did it for me and it was my first SSRI."

"I’m on Zoloft and it’s the only one that works for me."

"Sertraline worked best."

"Zoloft. Hands down. I take it every day."

"Sertraline probably saved my life."

"Zoloft worked wonders for me."

"I’m currently taking Zoloft. Made me gain a ton of weight but definitely helped my mental state"

"When I started Zoloft for the very first time, I felt amazing. Lots of energy, motivation, and very talkative."

"I've been on Zoloft since I was a pre-teen before any PCOS issues."

"I recently had to change to Zoloft and so far so good"

Venlafaxine

3.8

(24)

"Effexor by far"

"For me the only one that worked was Venlafaxine. Could feel a difference after only a few weeks."

"Venlafaxine ER has been great."

"Effexor 100%!"

"I’ve taken Effexor XR for years and have had great success with it."

"Effexor helped me a ton!"

"Effexor stopped this for me completely."

"Venlafaxine worked better than most with Lamictal added to it."

"Effexor"

"I’ve been on Effexor for a very very long time and it’s been consistently effective."

Mirtazapine

3.7

(22)

"I’ve finally started laughing at all my favourite shows again."

"It’s the only one I’ve taken that’s shown me what the correct anti depressant is supposed to do."

"Mirtazapine worked perfectly."

"Is great for anxiety and depression, and rarely ever cause sexual side effects"

"Help me."

"I feel better in my days, I can tidy up without overthinking everything."

"Mine is mirtazepine & trazodone. This, paired with Invega + mood stabilization, has given me a glimpse of what my life used to be."

"+1 for Mirtazipine."

"Main ones apart from mirtizapine are doxepin, amitriptyline, trazodone."

"I took mirtazapine and it helped me sleep amazing and didn’t spike my tinnitus."

#10

Prozac

4.1

(15)

"Prozac is one of the best ones for weight."

"I've been on Prozac for about three years now, and it hasn't made my pcos worse!"

"It has nuked my anxiety from being an agoraphobic."

"It’s helped me immensely."

"Prozac, and it’s niiiiiiiice. Life is good again."

"Prozac made me feel super happy but it’s very activating so not too good for anxiety if that’s what you’re trying to treat"

"So yeah i would recommend prozac lol"

"Fluoxetine really helped me."

"Both Prozac and Lexapro have worked very well."

"Fluoxetine in small dose with olanzapine or any other antipsychotic helped me."

#11

Trintellix

4.0

(13)

"Trintellix is the ssri that’s worked best for me personally"

"Trintellix w/ zero side effects"

"Trintillex changed my life"

"Trintellix is the most helpful with no side effects."

"I’ve heard good things about trintellix"

"Trintellix for me. Works better than Lexapro for me."

"Brintellix is fine for me. It helps a lot for anxiety."

"Trintellix, viibryd, mirtazapine also have low risk of sexual side effects."

"There is also some evidence from studies that trintellix may help anhedonia."

"I was only on trintellix for like 4 days because the nausea was so bad with it, I am not sure I was on it long enough to actually get an idea."

#12

Amitriptyline

4.3

(12)

"Amitryptaline is the best antidepressant, according to research."

"The best antidepressant is amitryptaline. But you probably should try fluoxetine or any other SSRI first."

"Amitriptyline. Why anyone would go from Remeron to SSRIs or SNRIs or Wellbutrin, I have no clue."

"My doctor recommended amitriptyline for neurological issues and it’s been a game changer for me."

"In about 2 years I have not had any noticeable side effects at all."

"The best thing to try would be amitriptyline/amoxapine."

"Amitriptyline or doxepin."

"Amitryptiline and chlomiprimene are good for treatment resistant."

"If it’s not amitriptyline, it could be Wellbutrin."

"Amitriptyline. My wife believes this is it from context."

#13

Lexapro

3.6

(14)

"It has legitimately been the first antidepressant with zero side effects that has improved my level of depression significantly."

"It’s the first antidepressant I’ve had with zero side effects."

"Lexapro changed my life."

"I’m on lexapro with strattera and it works great for me !"

"So far for me it’s Lexapro, Trintellix, and Zoloft, but only at low doses."

"Been on it for almost two years now"

"Escitalopram and citalopram are among the best-tolerated treatments."

"I believe Lexapro is one of the most secured medicine"

"Yes, Escitalopram can be used for depression and anxiety in Parkinson’s. It’s a decent med (that is, as far as meds go) as it’s considered a “clean” antidepressant (few side effects and drug interactions)."

"I think I felt 'the best' on a high dose of Cipralex(40mg) or on vortioxetinum 20 mg."

#14

Citalopram

4.2

(12)

"Citalopram helped me feel like a person again; off of it, I couldn’t even go to a gas station without freaking out"

"Citalopram did wonders for me."

"Then I was put on citalopram and its genuinely changed my life."

"Citalopram has eliminated my symptoms I wouldn’t be here without it."

"In my neck of the woods it's more often citalopram, escitalopram, venlafaxine or bupropion."

"Everyone is different. For me it's citalopram."

"Citalopram, which is what works best for me."

"I had good luck with citalopram at 10 or 20 milligrams."

"Celexa is the best med for anxiety alone."

"For me it’s been Citalopram."

#15

Paroxetine

3.3

(12)

"Paxil was amazing but put a lot of weight on it"

"Paroxetine/ Seroxat is great but must admit, extremely addictive."

"Only ssri that worked."

"It worked wonders for me! Made my anxiety disappear completely."

"Paxil from my experience."

"Paxil"

"Paxil may be a good choice"

"Paroxetine is known as the hardest to come off but with less side effects."

"Paroxetine. Mid doses 30/40mg"

"Paroxetine"

#16

Vortioxetine

4.0

(9)

"Vortioxetine, started it back in 2022 and it's still working. No poop out yet."

"Vortioxetine worked for me after trying 4 antidepressants before it."

"Vortioxetine"

"Vortioxetine 20mg helped me with treatment resistant depression at a time but it also lost effect."

"Trintellix seems to be helping me."

"Vortioxetine is the mainstream AD with the best RCT numbers against anhedonia."

"Trintellix."

"...then we tried vortioxetine and that was when everything felt really good."

"Vortioxetine"

#17

Cymbalta

4.1

(8)

"Cymbalta works best for me"

"Cymbalta works great for nerve pain."

"I do believe they’ve both helped in my SCI journey as well."

"I still take cymbalta. I couldn’t have broke out of the sadness without it."

"Cymbalta worked great for my nerve pain"

"I am on cymbalta and I think its a very effective drug for my nerve pain."

"Cymbalta and Effexor are often prescribed for pain."

"Stay away from cymbalta!"

#18

Auvelity

4.4

(7)

"I’m on Auvelity. It’s new and works extremely well."

"I’m on an amazing anti-depressant called Auvelity that was approved by the FDA."

"I’m on Auvelity and Lamictal- highly recommend the combo."

"I've seen other people with TRD have a good response to one of the new antidepressants, Auvelity, which is a combination of dextromethorphan/bupropion, it kinda works similarly to ketamine."

"Have you tried Auvelity which is fairly new."

"Auvelity has been a game changer for me."

"Havent tried it but Auvelity seems super interesting."

#19

Trazodone

4.8

(6)

"Trazodone been taking it for many years without any side effects or interactions very safe 100 mg at bedtime"

"Which completely changed my life."

"Trazodone. Probably the best stabilising/calming AD for me also, and feels pretty much side effect free."

"Trazodone, followed by mirtazapine."

"I'm on trazodone 100mg for a month now. I haven't had any side effects at all."

"I take trazodone at night that really helps my pain."

#20

Lamotrigine

4.0

(7)

"I have had great results from Lamictal."

"Lamotrigine helped me with this immensely. Most SSRIs made it worse. Zoloft helped a bit as well!"

"I have taken that for long periods for the depressive symptoms of a bipolar diagnosis."

"It is a mood stabilizer though"

"Lamotrigine seems like a good alternative."

"The thing that helped the most with my depression was getting on a mood stabilizer, which is lamotrigine."

"I’m on Lamictal and Effexor."

#21

Effexor

4.3

(6)

"It’s been AMAZING for me."

"Effexor have does wonders for me."

"Effexor and Wellbutrin"

"Effexor"

"Now I am on high dose Effexor(300mg) plus lamictal (200mg) plus quetiapine and I hope they continue to work as long as possible."

"Effexor has basically saved my life since starting it last year."

#22

Nortriptyline

4.2

(6)

"I'm on a low dose of Nortriptyline. It's done wonders for me."

"Nortriptyline and IV Ketamine. Taking both right now."

"Nortriptyline, Imipramine, Amitriptyline."

"I take nortriptyline (100mg) for anxiety/depression."

"I found nortryptiline helpful."

"I’m on a tricyclic antidepressant I think it’s called nortryptan and it’s been great for me."

#23

Tranylcypromine

4.6

(5)

"MAOI drugs tend to be the best especially parnate."

"Old MAOIs like parnate are by far the most effective."

"SSRIs don’t do anything compared to Parnate."

"Maybe Parnate."

"Tranylcypromine and Phenelzine."

#24

Clomipramine

3.7

(6)

"Clomipramine worked well for my treatment resistance unfortunately I could not tolerate it."

"Clomipramine."

"Currently on clomipramine and memantine and things are going ok."

"I’ve been taking Clomipramine for 9 days now, and it’s wonderful for OCD so far."

"Clomipramine is the best med for OCD."

"So far on: Clomipramin"

#25

Celexa

3.8

(5)

"I take celexa"

"I am finding celexa to be working for me."

"I take celexa. I wanted non habit forming when my psychiatrist diagnosed me with mild OCD."

"Celexa."

"Celexa and lexapro are great for me."

#26

Ketamine

4.8

(4)

"I did a course of the nasal spray for 8 weeks followed by maintenance and it got me out of the worst depression I’ve ever experienced"

"The absolute miracle drug for me is Ketamine."

"Ketamine. The only one without side effects for me"

"Ketamine"

#27

Agomelatine

3.6

(5)

"Agomelatine might be worth trying. It doesn't have any sexual side effects."

"Agomelatine, moclobemide, mirtizapine."

"Agomelatine won't cause sexual side effects but it's not available in all countries eg USA."

"Valdoxan is weak anti anxiety, antidepressant."

"Agomelatine. Moclobemide. St John's Wort."

#28

Nefazodone

4.3

(4)

"If you are in the U.S. you may want to take a look at nefazodone. It is effective for TRD and it has a low side effect profile."

"If you are in the U.S. nefazodone can be effective for those who are treatment resistant."

"For myself, it has been nefazodone."

"The ones with the lowest sexual side effects are nefazodone, mirtazapine, wellbutrin."

#29

Vilazodone

4.3

(4)

"Viibryd is the only medication that truly stabilized me."

"For me, it’s vilazodone, with a boost of bupropion for the winter."

"I'd try viibryd."

"Viibryd is a newer medication that has a built in mechanism that essentially lowers the risk of sexual side effects."

#30

Moclobemide

4.0

(4)

"Doesnt require a tyramine diet and has no negative sexual side effects."

"Most sides free (actually improve sexual functioning) are moclobemide, tianeptine, agomelatine, and bupropion."

"Moclobemide 300-600mg daily"

"So far on: Moclobemid"

#31

Genesight

4.7

(3)

"Helped me soooo much, was really worth it so i didnt have to keep doing guess work about my meds."

"I highly recommend getting your PCP to do the Genesight test so you can find out what medication works best for your body!"

"Have you heard of GeneSight? It’s a genetic test that evaluates how you may respond to different antidepressants."

#32

Desvenlafaxine

3.5

4.0

(3)

"Has been working like a charm for me"

"Same story, but this is for primary anxiety without depression."

"I’ve heard that adding buspirone to an ssri can help. I tried it, but could not tolerate because the buspirone gave me bad headaches."

#39

Parnate

5.0

(2)

"For me, Parnate (tranylcypromine) did the trick for my depression-induced brain fog."

"Parnate Nardil the nukes 💣"

#40

Quetiapine

2.5

(4)

3.0

(1)

"Consider exploring guanfacine, adderall, Modafinil or Memantine."

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