Antihistamines reviews from Reddit
Summary
We analyzed 261 Reddit reviews across 32 subreddits and 63 posts to rank the best Antihistamines brands recommended by redditors, including communities like r/MCAS, r/covidlonghaulers, r/newzealand, r/Netherlands, r/LongCovid. Top-rated brands include Zyrtec (4.0/5), Allegra (4.1/5), Cetirizine (4.1/5).
Stats
Reviews261
Subreddits32
Posts63
Brands63
Products12
261 reviews from
and
By Brand
/By Product
#1
Zyrtec
4.0
(39)
"My doctor started me on Zyrtec and Pepcid twice a day and it really helped!"
"Antihistamines (I’ve also taken loratadine and fexofenadine) have had absol"
"I'm on a monthly regimen of allergy shots and I take Zyrtec and Flonase daily."
"Tbh taking Zyrtec twice a day so my hands and feet don’t itch is we’ll worth it IMO."
"Zirtec starts working well after at least 6 days... has become my best friend."
"...she put me on zyrtec twice a day... it does work a LOT better."
"I take Zyrtec daily and I’m fine."
"Zyrtec is good to me"
"I'm taking Zyrtec (cetirizine) once a day."
"Zyrtec. I tried Desloratadine, but I sleep better after Zyrtec."
#2
Allegra
4.1
(26)
"Fexofenadine (think it's Allegra in the US) along with Famotidine. The combo did the trick"
"Allegra for me."
"Fexofenadine and loratadine have far lower rates of side effects like drowsiness."
"I’m been on Allegra for 15 years, daily."
"Yes!!! It has helped me a lot!!! For 6 months I had 24/7 headaches."
"Allegra, life changing... relieves these symptoms in 30 minutes or less."
"My sons eczema cleared up with Allegra and Singulair."
"I take 1x Allegra and 2x Pepcid in the morning."
"Have you tried switching antihistamines? I can’t use Zyrtec for instance because of this reason, but Allegra I have no problem with."
"Taking Allegra everyday has provided so much relief."
#3
Cetirizine
4.1
(24)
"Zyrtec was my God send"
"They really work for dog+cat allergies."
"Has always worked for me, and they're the cheapest."
"That does the trick"
"My daily antihistamines are cetirizine and famotidine."
"Cetirizine"
"I take cetirizine 4x daily, I was told it's the standard guidance."
"I now take 40 mg of cetirizine. I was taking loratadine before that."
"...beats being itchy."
"Under 7 Euro for 100 tablets. That's a LOT better than Kruidvat's generic price of 4.50 for 21 tablets."
#4
Loratadine
4.2
(19)
"Yes!!! I take loratadine and famotidine daily for MCAS symptoms and it really helps me with some pain."
"This year loratadine has fixed me up."
"Seems to help me 100%."
"Loratadine and famotidine twice daily."
"Loratadine"
"Loratadine + Famotidine helps a lot."
"I settled on loratadine, it works great."
"I use loratadine in season and it doesn’t affect my ability to focus."
"I get really sleepy from cetirizine, but am mostly fine with loratadine."
"I always had those from kruidvat or etos. These have the ingredients like loratadine and cetirizine."
#5
Hydroxyzine
4.6
(13)
"Hydroxyzine has been my saving grace against panic attacks."
"Hydroxyzine makes me nice & sleepy."
"The antihistamine that helped me the most was without hesitation hydroxyzine."
"I think hydroxine/atarax is the best for you."
"I was prescribed hydroxzine HCL. Worked incredible."
"Worked really well for me."
"Has helped me the absolute most."
"Can be taken as-needed."
"Hydroxyzine works for me, although I'm on the lowest possible dose."
"Hydroxyzine has been helping me."
#6
Claritin
3.9
(15)
"I've tried Claritin, Allegra, and Xyzal. They are miracle workers for my sinus headaches though."
"Claritin and Xyzal"
"Claritin in the morning with food"
"I just finished week 3 and take the Target brand of Claritin."
"Most people find loratidine and fenofexadine the least sedating."
"I don’t have to take Claritin on a daily basis anymore."
"Low histamine foods plus claritin twice a day is the only thing that keeps me relatively stable."
"Claritin helps me with joint pain and swelling, and dramatically reduces how many adrenaline dump/PEM episodes I get"
"I recommend: Cold compresses/ice packs, looser clothes, antihistamines (for a few weeks)."
"I was x2 a day Claritin (am and pm); just the regular Claritin, not Claritin-D."
#7
Fexofenadine
4.3
(9)
"Mine is anything with fexofenadine.. only thing that has worked for me!"
"Has treated me really well."
"As strong as Telfast 180 and 1/3 of the price."
"I'm on fexofenadine 180mg 2x a day, and famotadine 20mg 2x a day."
"I found the most relief during my luteal phase using a combo of fexofenidine and famotidine."
"I take Fexofenadine, I'm not sure what the brand names would be in your area."
"Get Fexofenadine. No sleep effect. Prescribed though."
"Could be worth a try"
"I'm personally on Fexofenadine and occasionally Chlorphenamine."
#8
Benadryl
4.1
(7)
"Benadryl is consistently the most effective."
"Benadryl has been the best for me."
"Benedryl has been best for me, but I try not to use it due to side effects."
"The basic protocol is: - Benadryl (dipenhydramine hydrochloride) 50mg at night - Claritin (loratadine) 10mg in the morning - Pepcid 20mg twice daily"
"I’ve had luck with plain old Benadryl."
"Benadryl helps when I’m having a mild flare from my period or ovulation."
"For me: benadryl and pepcid. but my allergist has me on allegra & pepcid daily."
#9
Cromolyn
4.0
(7)
"Cromolyn made a BIG difference. It helped a lot."
"Cromolyn Sodium nasal spray helped and still does."
"Cromolyn sodium helped all my GI issues."
"Cromolyn and progesterone has helped me immensely."
"I take cromolyn orally and nebulized."
"Cromolyn sodium helped my GI issues."
"It’s also a pretty obscure medicine, but it’s the one that works best."
#10
Singulair
4.0
(7)
"Try adding singulair and Pepcid."
"You've got other medical options - like singulair, flovent/flonase, allergy shots."
"Prescription Singulair really helps me during those intense allergy periods."
"Singular worked well for my daughter’s severe asthma."
"I have to take both. Singulair made a huge difference in my breathing and allergy cough."
"I take Singulair and zyrtec."
"Ask your doctor about increasing the dosage, or if they'll prescribe singulair."
#11
Xyzal
4.0
(6)
"Xyzal has worked best for me so far!"
"I'm on Xyzal now and my primary care provider recommended taking any (24 hr) allergy med a while before bed."
"I started with xyzal and then to Claritin."
"Currently I swear by Xyzal."
"Zyzal if they have it, Zyrtec if they don't have zyzal."
"Xyzal works the best for me, but I get too sleepy."
#12
Desloratadine
4.4
(5)
"GP proscribed me desloratadine which I’ve been using for years. Works like a charm and I’ve never felt any side effects."
"Ask your GP for desloratadine! I get insanely drowsy from all the other ones, except for this one :) "
"Desloratadine is the most effective on me."
"Desloratadine"
"I take 5mg desloratadine and and 10mg Montelukast."
#13
Xolair
4.2
(5)
"Xolair cured my hives! I suffered for a long time."
"Xolair tried to kill me at all doses."
"Xolair has helped me along with antihistamines."
"I’m on my 4th month of xolair injections and it is helping."
"Xolair definitely helped to the point I stopped taking antihistamines completely."
#14
Antihistamines
3.8
(5)
"Antihistamines worked so could be worth a try - maybe check with your dr?"
"You can certainly try antihistamines, no harm in trying!"
"Second generation for your need. I use first gen cause second gens just don't cut it for me in terms of relief"
"I read an article on here about antihistamines so I started probably ten days ago and tbh I am delighted."
"Make sure to rotate your antihistamines, your body gets used to them after a while."
#15
Nettle
4.3
(4)
"I was doing the nettle tea and found it to make a big difference."
"I use nettle :) but just when the symptoms are sneezy/sinus stuff."
"Nettles, local honey"
"Nettle, goldenrod, and ground ivy (*Glechoma hederacea*) are three that come to mind with anti histamine properties."
#16
Bilastine
4.3
(3)
"Blexten/Bilastine is fantastic"
"Personally I find bilastine the best."
"They've really worked for me, totally worth it."
#17
Famotidine
4.3
(3)
"H2 antagonists like famotidine actually work wayyyy better for me than H1 antihistamines!"
"Famotidine"
"I find that the combination of Famotidine (H2 blocker) and Desloratadine helps."
#18
Flonase
4.0
(3)
"I started taking Zyrtec and Flonase every morning."
"I’d jump to nasal corticosteroids. Different mechanism of action and different set of potential side-effects, but no drowsiness concerns."
"I used Flonase with some success."
#19
Fluticasone
4.0
(3)
"Fluticanosa works well. loratadine / ceriticine are also good."
"I try to only use it when I need it."
"I'll echo everyone else - Flixonase."
#20
Levocetirizine
4.0
(3)
"I’m also using levocetirizine. It has the fewest side effects for me."
"Only a combination of levocetrizine (prescription) and azelastine spray/eyedrops work."
"I personally use Xyzal and Ketotifen as my primaries."
#21
Ketotifen
4.0
(3)
"Ketotifen was the first drug that actually had a profound effect for me."
"KETOTIFEN do not sleep on that one"
"The best thing for me has been a mast cell stabiliser Ketotifen."
#22
Pepcid
3.7
(3)
"It has to be an H2 antihistamine (like Pepcid aka famotidine)..."
"It really helps some people. My husband does just as well on Pepcid as he does on Claritin."
"For me the H1 antihistamines did not help, but the H2 (Pepcid) does help."
#23
Blexten
4.5
(2)
"I’ve been on blexten for almost 2 years and it didn’t cause me to gain weight."
"Try Blexten."
#24
Rupatadine
4.5
(2)
"I’ve been on daily rupall (rupatadine) for 2 years and I’ve been losing weight."
"Combo of famotadine 40 mg twice a day and rupatadine 10 mg."
#25
Diphenhydramine
4.0
(2)
"Is diphenhydramine available? It is OTC in most parts of Europe and drowsiness is a side effect."
"I've had some luck with benadryl and hydroxyzine."
#26
Quercetin
4.0
(2)
"Quercetin and nettles, local honey and bee pollen are some I’ve used with okay results."
"It really has helped me a lot!"
#27
Promethazine
4.0
(2)
"Promethazine (Phenergan) - helps with my MCAS & vertigo."
"Works for me"
#28
Montelukast
4.0
(2)
"I take both montelukast and cetirizine. They are both helpful."
"The anti histamines did help but I also needed montelukast."
#29
Chlorphenamine
4.0
(2)
"Chlorphenamine is best, but also consider promethazine, hydroxyzine, and as a last resort: benadryl."
"Chlorphenamine 4mg and Pepcid... 70% success rate with Chlorphenamine"
#30
Chlorpheniramine
3.5
(2)
"I'm trialling chlorpheniramine nightly, polarimine mornings."
"Chlorpheniramine is the only pharmaceutical antihistamine I c"
#31
Solgar
5.0
(1)
"Great for allergies & immune support in my experience."
#32
Turmeric
5.0
(1)
"I have no idea how, but at least ime turmeric (+ black pepper for absorption) without a _doubt_ works wonders for my allergies."
#33
Vimergy
5.0
(1)
"Another natural antihistamine is nettle. Vimergy makes a great alcohol-free tincture"
#34
Azelastine
5.0
(1)
"I'm having great success with it, I use it twice a day."
#35
Budesonide
5.0
(1)
"Been using Budosenide nose spray since last year and it works way better while having close to zero side effects!"
#36
Xlear
5.0
(1)
"Xlear works for me. Plus it has no rebound effect."
#37
Stinging Nettle
5.0
(1)
"It’s a natural antihistamine :)"
#38
Nettle Tea
5.0
(1)
"Stinging nettle tea is a natural antihistamine."
#39
Aller-G Plus
4.0
(1)
"I use this - https://www.naturalathleteclinic.com/products/aller-g-plus-by-mountain-peak-nutritionals"
#40
Pure Encapsulations
4.0
(1)
"It's my pollen season go-to, but it does have side effects."
#41
Telfast
4.0
(1)
"Have a look at telfast 180mg. They come in large packs as well which helps."
#42
Cyproheptadine
4.0
(1)
"Cyproheptadine is a really good one because it acts in a generally anti-stress way."
#43
Melatonin
4.0
(1)
"Melatonin gummies work great for me."
#44
Genexa
4.0
(1)
"It's an all natural version to the normal brands we are used to."
#45
Pepcid AC
4.0
(1)
"I added Pepcid AC (works on histamine receptors in gut)."
#46
Allerfree
4.0
(1)
"I have very good results with Allerfre."
#47
Dymista
4.0
(1)
"I run dymista nose spray and labixten tablets."
#48
Equilife
4.0
(1)
"I use equilife supplements and they have one for allergies."
#49
Homeopathic
4.0
(1)
"Homeopathic remedy can be found at health food stores or Amazon."
#50
Alvesco
4.0
(1)
"I also take Alvesco which is similar to singular and symbicort."
#51
Rupatidine
4.0
(1)
"Rupatidin is nice for not having drowziness, but you need prescription."
#52
Compounded Antihistamines
4.0
(1)
"Have you tried compounded antihistamines? Many of us react to the inactive ingredients in drugs."
#53
Flovent
4.0
(1)
"You've got other medical options - like singulair, flovent/flonase, allergy shots."
#54
Costco Antihistamines
4.0
(1)
"I hunted for some from the US on eBay/Amazon. I got 365 tablets delivered to NZ for $14."
#55
Rupall
4.0
(1)
"Rupall seems to be an extra potent PAF inhibitor."
#56
Visitaril
4.0
(1)
"I am prescribed visitaril for my anxiety. It is an antihistamine that has sedative properties that helps treat anxiety and tension."
#57
Black Seed Oil
4.0
(1)
"I'll have some black seed oil and drink rosemary tea and I'll clear up immediately."
#58
Garlic and Horseradish
4.0
(1)
"Garlic and horseradish are common capsules for allergies."
#59
Berberine
4.0
(1)
"I also second Pepcid, I only need it during spring tree season normally but it definitely helps."
#60
H2 Antihistamines
4.0
(1)
"I take H2 antihistamines when I have acute breathing issues and they help a lot."
#61
Second Generation Antihistamines
3.0
(1)
"You should look at second Gen antihistamines, in the US that's Allegra, Claritin, Zyrtec and Xyzal."
#62
Pollen Protect
3.0
(1)
"I’m trying the following Ayurvedic combo (as tablets labeled “Pollen Protect” by Banyan Botanicals)"
#63
Flixonase
3.0
(1)
"Sterile neti pots are also a nice alt to flixonase (which doesn’t always work great for me)."
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