r/MTHFR is a subreddit with 32k members. The most common kinds of discussions are advice requests and pain & anger, and the community frequently discusses mthfr, supplements, methylation, b12, and struggling, and they frequently recommend/review sleep aids, vitamin, and multivitamin.
This subreddit is dedicated to those wanting to learn more and discuss the MTHFR (Methylene tetra hydro folate reductase) gene mutation.
Popular Themes in r/MTHFR
#1
Advice Requests
: "Importance of potassium while on folate and b12"
15 posts
#2
Pain & Anger
: "Why do doctors ignore MTHFR when its ruining everything?"
4 posts
#3
Self-Promotion
: "I built a tool that analyzes your raw 23andMe (and others) DNA file and creates a personalized supplement protocol. Happy to answer questions."
3 posts
#4
Solution Requests
: "I built a tool to make sense of MTHFR/COMT/MAO-A. Need your feedback (free beta access)."
1 post
Popular Topics in r/MTHFR
#1
Mthfr
: "Why do doctors ignore Mthfr when its ruining everything?"
133 posts
#2
Supplements
: "Anyone with MTHFR managed their ADHD symptoms through using Supplements?"
60 posts
#3
Methylation
: "A Speculative Theory Linking Methylation, Neck Issues and Chronic Multisystem Illnesses"
39 posts
#4
B12
: "Normal Labs, 4 Years of B12 Supplements, but Hidden B12 Deficiency(Celiac + High Folate + Neuro Symptoms) My Experience"
32 posts
#5
Struggling
28 posts
#6
Folate
: "Diagnosed with a homocysteine of 90, a Folate deficiency of 2.7, and a B12 deficiency of 180 (I need help please)"
25 posts
#7
Results
: "Spent a year mapping what my MTHFR Results were actually pointing to downstream."
24 posts
#8
Advice
: "Slow COMT building a supplement stack looking for Advice and critique"
21 posts
#9
Anxiety
: "Anyone else double slow comt and have lifelong Anxiety ?"
20 posts
#10
Comt
: "I created a tool to help make sense of MTHFR/Comt/MAO-A. Need your feedback (free beta access)"
19 posts
Products Discussed in r/MTHFR
Sleep Aids
6 reviews
#1
Healthy Cell REM Sleep
3.0★ from 1 review
#2
SAMe
4.0★ from 1 review
#3
Meclizine
4.0★ from 1 review
Vitamin
3 reviews
#1
Seeking Health
5.0★ from 2 reviews
#2
10X Health
5.0★ from 1 review
Multivitamin
2 reviews
#1
Seeking Health
4.0★ from 1 review
#2
Thorne
4.0★ from 1 review
Flair Used in r/MTHFR
#1
Question
: "Does anyone else call this the mother fucker gene? The first time I talked about it, it naturally rolled off my tongue that way. 👅"
137 posts
#2
Results Discussion
: "Your anxiety might not actually be anxiety.. At least not the way you've been told."
35 posts
#3
Resource
: "A Decade of Fatigue and Unusual Symptoms - with an Unusual Resolution"
28 posts
Member Growth in r/MTHFR
Yearly
+8k members(31.3%)
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Last updated: June 15, 2026