r/MTHFR is a subreddit with 33k members. The community frequently discusses mthfr, supplements, methylation, b12, and struggling, and they frequently recommend/review sleep aids, vitamin, and multivitamin, and the most common flair used is question, results discussion, and resource.
This subreddit is dedicated to those wanting to learn more and discuss the MTHFR (Methylene tetra hydro folate reductase) gene mutation.
Popular Topics in r/MTHFR
#1
Mthfr
133 posts
#2
Supplements
60 posts
#3
Methylation
39 posts
#4
B12
32 posts
#5
Struggling
28 posts
#6
Folate
25 posts
#7
Results
24 posts
#8
Advice
21 posts
#9
Anxiety
20 posts
#10
Comt
19 posts
Products Discussed in r/MTHFR
Sleep Aids
6 reviews
#1
Healthy Cell REM Sleep
3.0★ from 1 review
#2
SAMe
4.0★ from 1 review
#3
Meclizine
4.0★ from 1 review
Vitamin
3 reviews
#1
Seeking Health
5.0★ from 2 reviews
#2
10X Health
5.0★ from 1 review
Multivitamin
2 reviews
#1
Seeking Health
4.0★ from 1 review
#2
Thorne
4.0★ from 1 review
Flair Used in r/MTHFR
#1
Question
: "Has anyone actually improved lifelong anxiety by addressing genetic variants and nutrient deficiencies?"
148 posts
#2
Results Discussion
: "Your brain clears dopamine up to 3-4x faster than slow COMT carriers. Thats why you feel dead inside despite doing everything right"
23 posts
#3
Resource
: "Creatine is not just a gym supplement — here is why people with MTHFR, B12 deficiency, and active neurological recovery should know about its methyl sparing, detox, neuroprotection, and brain clearing effects"
6 posts
Member Growth in r/MTHFR
Yearly
+7k members(26.1%)
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Last updated: August 12, 2026