Anti-depressant reviews from Reddit
Summary
We analyzed 189 Reddit reviews across 21 subreddits and 36 posts to rank the best Anti-depressant brands recommended by redditors, including communities like r/antidepressants, r/BPD, r/AskReddit, r/ibs, r/Menopause. Top-rated brands include Wellbutrin (4.3/5), Mirtazapine (3.7/5), Prozac (4.3/5).
Stats
Reviews189
Subreddits21
Posts36
Brands66
Products8
189 reviews from
and
By Brand
/By Product
#1
Wellbutrin
4.3
(24)
"It makes me feel positive about life, but I also don't have to endure the god awful side effects of SSRI's."
"Wellbutrin and lexapro is the best combination for me."
"Wellbutrin as well"
"Singlehandedly transformed and/or completely reformed my prior spiraling mental health state."
"I recently started Wellbutrin and I am feeling great!"
"Wellbutrin was the only one that the average actually lost 2lbs."
"Wellbutrin."
"Adding Wellbutrin two months ago has made me feel normal again."
"It was my miracle drug, it is the only thing that has ever worked for my depression, adhd, and anxiety."
"For me what finally worked was Bupropion (Wellbutrin) + Lithium for augmentation."
#2
Mirtazapine
3.7
(15)
"Mirtazipine does a fantastic job at this. It's the best known antidepressant with this side effect."
"It’s the only thing keeping me going at this point."
"Mirtazapine is sometimes off label used for skin conditions. My eczema completely disappeared and never came back after six months on Mirtazapine."
"Mirtazapine is also good for that."
"I'd say mirtazapine, but it DOES cause drowsiness."
"Super effective antidepressant that causes weight gain and is even prescribed to patients in order to help them gain weight."
"Mirtzapine"
"If you normally have bad luck with side effects from ADs talk to your doctor about starting you on low dose mirtazepine, like 7.5mg to start."
"Mirtazapine"
"Mirtazapine"
#3
Prozac
4.3
(13)
"I love my old timey prozac."
"Hands down Fluoxetine (Prozac) for me."
"I switched to prozac and it has been a total life changer."
"I started Prozac 20mg and Seroquel 25mg... and by day 8 I felt great."
"I just changed from Celexa to Prozac and it helped me tremendously."
"I've taken (and have recently restarted) Prozac as it has really helped me."
"I’m now on a mix of hormones, Prozac and sleep aids. I feel better than I have in years."
"I would recommend prozac or zoloft before trying effexor."
"My friend swears by Prozac."
"Prozac helps a lot"
#4
Paxil
4.2
(11)
"Paxil quite literally saved my life."
"Works for me."
"It can be a useful option for women who can’t do hormones."
"Paxil"
"Paxil is great for that, but lot of weight gain and withdrawal is though"
"A lot of people are going to disagree with me but: Paxil. I never had any bad side effects."
"Paxil. Cymbalta. Those are the two I've had success with anyways."
"Is working for me."
"Paxil"
"Paxil <3"
#5
Lexapro
4.4
(9)
"Tbh i hear lexapro is amazing for anxiety from every person who i’ve talked to that’s on it"
"Lexapro."
"Works amazingly well for me."
"Anxiety GONE."
"It has saved my life 3x now and works every time I need to go back on it."
"Lexapro is great for anxiety and mood but it doesn’t really have an affect on motivation."
"Lexapro helped but I had weight gain as a side effect."
"I’m currently on lexapro and it’s helped so far."
"I’ve only taken lexapro, but it worked really well for social anxiety."
#6
Zoloft
4.3
(8)
"I’m on Zoloft and it has helped a lot :) "
"I think that was probably the best med I got on."
"In my experience, Zoloft has been amazing for panic disorder... it seriously changed (and saved) my life."
"Zoloft took a while to get going for my anxiety."
"Works for me."
"2 - Sertraline / Zoloft (started at 50mg/day, gradually increased to 200mg) Improvement lasted 4 months, then 'pooped out'."
"Helped me but it also gave me horrible memory problems."
#7
Effexor
4.0
(7)
"Helps me keep the migraines, and the anxiety triggers, to a minimum."
"It’s very individual, but for me it’s Effexor."
"Combination of Effexor and Abilify."
"The most effective meds were: 1 - Venlafaxine / Effexor (started at 75mg/day, gradually increased to 225mg) Improvement lasted 5 months, then 'poop out' effect aka tachyphylaxis."
"Effexor is the only one that worked for me"
"I tried many, but the first that worked it was venlafexine."
"I’ve been on 37.5mg of Effexor and now I have to switch to different meds because my meds suddenly stopped working."
#8
Sertraline
4.2
(6)
"Sertraline has done wonders for me."
"I'm doing much better."
"We're currently on sertraline (SSRI) and it's a tonne better for us."
"The most manageable side effects I've had have been dealing with weight gain from sertraline."
"Sertraline 150mg/day"
"I take 200mg’s daily of Sertraline"
#9
Cymbalta
3.8
(6)
"Cymbalta was a game changer for me."
"Cymbalta was a life saver for me!"
"It helped tremendously with my Ibs-d."
"Since Effexor helped, trying Cymbalta might be an option since they’re similar?"
"I was recently started on Cymbalta too for my chronic pain. I haven’t noticed a difference but I also feel like it hasn’t made my OCD worse."
"It slightly took the edge off my pain."
#10
Citalopram
4.4
(5)
"The 2 pill combination really works for me"
"Citalopram has been an absolute lifesaver."
"Has increased my sex drive like crazy!!"
"I've been on citalopram for almost fifteen years."
"Citalopram for me"
#11
Trintellix
4.0
(5)
"This was the only one that's working without weight gain, fatigue, or insomnia"
"I'm on a combination of Trintellix, Wellbutrin and psychotherapy."
"Trintelix."
"The least potential for sexual side effects."
"Trintellix"
#12
Amitriptyline
4.0
(5)
"It works really well for me."
"Amitriptyline"
"I had some luck with amitriptyline."
"9 weeks on amitriptyline and it's been amazing for me."
"It worked for a couple weeks and then wore off."
#13
Pristiq
5.0
(4)
"Only Pristiq has helped with my depression."
"Has been the best for me."
"Has worked great for me."
"Pristiq is the only one I’ve ever tried - turned my life around"
#14
Fluoxetine
4.3
(4)
"Turn me around each time. Life saver."
"Very useful."
"There are people who do well on fluoxetine and Venlafaxine."
"Is only one that hasn't interfered."
#15
Lamotrigine
4.7
(3)
"The one that does the most for me is my Lamotrigine."
"Lamotrigine. It's an amazing med."
"Lamotrigine, paroxetine and trintellix."
#16
Nefazodone
4.7
(3)
"Nefazodone has worked best for myself, zoloft 2nd."
"The only one that significantly lowers my anxiety."
"The least sexual side effects."
#17
Nortriptyline
4.0
(3)
"It was the first thing I found to help me have even a few 'normalish' days a week."
"I took nortriptyline (an anti depressant) to treat my migraines."
"I have been on a few tricyclic antidepressants, including nortriptyline."
#18
Venlafaxine
4.0
(3)
"It's been very very good for me."
"Venlafaxine for me. No other antidepressant touched my anxiety."
"You'll feel like your symptoms never existed."
#19
Agomelatine
4.0
(3)
"Agomelatine"
"Find it works for me."
#20
Propranolol
4.5
(2)
"Have not had a panic attack in years."
"Propranolol helped stop the physical symptoms when I was in my hardest times."
#21
Duloxetine
4.0
(2)
"Has actually helped with my low mood."
"Duloxetine, my appetite has gone away"
#22
SNRI
4.0
(2)
"An SNRI is what worked for me personally."
"Really helped with my depression."
#23
Pregabalin
4.0
(2)
"Very good for anxiety."
"Helped me with general anxiety a lot."
#24
SNRIs
3.5
(2)
"I would try it, honestly."
"SSRIs like Paxil, Zoloft and Lexapro sucked."
#25
Mianserin
5.0
(1)
"A life saver!"
#26
Serimel
5.0
(1)
"It's definitely helping my depression I feel less low and happier"
#27
EPITEC
5.0
(1)
"It's worked pretty well."
#28
SSRIs
5.0
(1)
"SSRIs are usually the front."
#29
Trazodone
5.0
(1)
"It helps so much."
#30
Tianeptine
5.0
(1)
"The best antidepressant that I ever had."
#31
Ketamine
5.0
(1)
"Shit is life changing."
#32
Genetic Testing
5.0
(1)
"This was a godsend for me."
#33
GeneSight
5.0
(1)
"I HIGHLY suggest getting a GeneSight test done. It shows you what meds work best for you, genetically."
#34
Estrogen and Progesterone
5.0
(1)
"Once I was finally prescribed, estrogen and progesterone, it has made all the difference in my mood."
#35
Oxcarbazepine
5.0
(1)
"My saviour has been oxcarbazepine."
#36
Tricyclic Antidepressant (TCA)
5.0
(1)
"I was on TCA for chronic headaches when I was 16, not yet diagnosed with migraines, and it worked wonderfully."
#37
Slime Rancher
5.0
(1)
"Slime Rancher has always brought me feelings of glee."
#38
Spider-Man: Into the Spider-Verse
5.0
(1)
"It has all a good feel-good-movie needs."
#39
The LOTR trilogy
5.0
(1)
"Those movies... are just so uplifting"
#40
Spravato
5.0
(1)
"I recommend taking it. Presumably everyone who is trying spravato has tried and failed at least 2 antidepressants."
#41
Lithium
5.0
(1)
"I was amazed at how effective Lithium is in combating depression."
#42
Celexa
5.0
(1)
"Taking celex rn 20mg :) it is my life saver, literally."
#43
Doxepin
4.0
(1)
"Its a TCA but gee its effective."
#44
Clonazepam
4.0
(1)
"I'm on clonazepam. It works."
#45
Vortioxetine
4.0
(1)
"Vortioxetine, Wellbutrin and Parnate."
#46
Strattera
4.0
(1)
"I'd definitely recommend trying Atomoxetine (Strattera)."
#47
Buspar
4.0
(1)
"It does take away a lot of the 'background anxiety'."
#48
Desvenlafaxine
4.0
(1)
"I don’t have any sexual side effects."
#49
Nardil
4.0
(1)
"It’s like being drunk all the time."
#50
Clomipramine
4.0
(1)
"I love it."
#51
Luvox
4.0
(1)
"Helped me a lot."
#52
Modafinil
4.0
(1)
"To boost my energy."
#53
Parnate
4.0
(1)
"Has been better."
#54
Valdoxan
4.0
(1)
#55
Pristique
4.0
(1)
"I take Pristique with Reglan and have had no issues so far."
#56
Viibryd
4.0
(1)
"I’m on Viibryd right now and I’m also on a beta blocker. I’ve been on the 20mg of Viibryd for 6 months now and I can see it starting to help a lot."
#57
Antidepressant
4.0
(1)
"I’m prescribed an anti depressant for pain because it’s used for chronic pain as well!"
#58
Moclobemide
4.0
(1)
"MAOIs are much better than SSRIs for sexual sides."
#59
SSRI
4.0
(1)
"They prescribed an SSRI and my life changed."
#60
Emsam
4.0
(1)
"Emsam doesn't cause shaking so much that it was originally approved for Parkinson's."
#61
Venlafaxine ER
4.0
(1)
"Venlafaxine er 75mg has been working for me."
#62
Antidepressants
3.0
(1)
"The effects (both positive and negative) were pretty mild."
#63
Various Antidepressants
3.0
(1)
"I've been on a couple different antidepressants for migraines. Not sure they actually helped but I didn't have any direct adverse effects."
#64
Lamictal
2.0
(1)
"Made me feel worse."
#65
Abilify
2.0
(1)
"My husband was on two prescribed and they started causing diabetic neuropathy symptoms."
#66
Paroxetine
2.0
(1)
"Paxil made my appetite non existent"
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